How Alloderm Works


Human tissue is constantly remaking itself through a process called remodeling. The cells and structure of your skin are completely replaced with new tissue every several months. This process keeps your tissue healthy. Remodeling works when special proteins in your tissue tell the body that tissue needs to be replaced. Human tissue has these proteins naturally. But once you have lost tissue-for instance, after an accident, burn, or surgery - your body loses the proteins needed to remodel the tissue. Normal tissue will not regrow. That's how scars are formed.

AlloDerm is an acellular dermal matrix designed to serve as a biologic scaffold for normal tissue remodeling. AlloDerm contains both the structure and the biochemical information to direct normal revascularization and cell repopulation as blood vessels, collagens, proteoglycans and elastin are preserved. This extracellular matrix contains the blood vessel channels which serve as conduits for revascularization; collagens, proteoglycans and elastin provide structure and information for cell repopulation; most importantly, preserved proteoglycans and proteins direct the patient's own cells to initiate revascularization and cell repopulation.

Merging Layers


With time, vascularization of the Alloderm graft takes place. Your body begins to accept the new layers of tissue by sending small blood vessels and other components needed for tissue survival. In the course of 7-10 days, the Alloderm graft begins to have it's own blood supply supplied by your body.

Day 7-10


By day 7 to 10 host fibroblast cells and blood vessels respond to the transplantation of the AlloDerm matrix initiating the revascularization and normal tissue remodeling process.

Day 45


Replacement and revascularization of the transplant continues as normal connective tissue forms through host collagen deposition.

By Day 90


AlloDerm repopulated with the patient's own cells has become integrated as the patient's own natural soft tissue. Fibroblasts continue to lay down autologous collagen.

By Day 180


AlloDerm is naturally remodeled into the patient's own tissue 6 to 8 months after the procedure. The healing process culminates in natural tissue remodeling, with no fibrosis.

Penis Enlargement Surgery :: Medical Enlargement :: Alloderm :: How it works

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